Haematology

Does every black necrotic lesion need surgical debridement?

Mohamed Shoukry, Jose De Lafunte and Muhammad S. Choudhry

A 4-year-old boy with beta-thalassemia major who underwent a successful bone marrow transplant (BMT), presented with a necrotic looking scalp lesion. Debridement was initially suggested but a punch biopsy showed Aspergillus fumigatus. Antifungal therapy was commenced and the lesion healed with minimal scarring. Invasive fungal infections are a major cause of morbidity and...

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(Vol 11 p 66-69, Dermatology; Haematology; Paediatric Surgery: 12 August 2011)

Amyloid light-chain amyloidosis, myeloma and autonomic neuropathy

John Chan, Arvind Sangwaiya and Jayantha Arnold

Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary...

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(Vol 11 p 56-59, Haematology; Histopathology; Nephrology; Neurology; Pathology; Radiology: 18 July 2011)

Fatal very late stent thrombosis in a paclitaxel-eluting stent after treatment of gastrointestinal bleeding: a case report

Miranda C.A. Kramer, Marcel A. Beijk, Allard C. van der Wal and Robbert J. de Winter

We describe a case of very late stent thrombosis (ST) in a patient presenting with hematemesis while taking aspirin and oral anticoagulation therapy (OAC). This case shows that the management of patients with an indication for OAC who undergo percutaneous coronary intervention with drug-eluting stent (DES) implantation is challenging because of the need to balance the...

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(Vol 11 p 48-52, Cardiology; Emergency Medicine; Gastroenterology; Haematology; Histopathology; Pathology: 18 July 2011)

Pure red cell aplasia in a patient with lupus-like disease and thymoma

Satveer Mankia and Ian P. Giles

Pure red cell aplasia (PRCA) is a rare complication of autoimmune rheumatic diseases such as systemic lupus erythematosus (SLE). Thymoma occurs in 5–13% of patients with PRCA and in 2% of patients with SLE. The simultaneous occurrence, however, of all 3 disorders is rare. We report a patient with lupus-like disease who developed PRCA in association with a...

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(Vol 11 p 37-40, Haematology; Rheumatology: 14 June 2011)

Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report

Jeremiah D. Dreisbach, Luke P. Dreisbach, David E. Young and Philip B. Dreisbach

Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII inhibitor and lupus anticoagulant. Clinical findings included large hemorrhagic areas of the extremities, a prolonged activated partial thrombin time (aPTT) that...

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(Vol 10 p 19-24, Haematology; Oncology: 6 April 2010)

Contents by specialty

Editor-in-Chief

Frank Cross

Consultant Surgeon

St. Bartholomew's and The London NHS Trust, UK

Editors

Neil Barnes

Consultant Physician

St. Bartholomew's and The London NHS Trust, UK

Ali Jawad

Consultant Rheumatologist

St. Bartholomew's and The London NHS Trust, UK