Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
Jeremiah D. Dreisbach, Luke P. Dreisbach, David E. Young and Philip B. Dreisbach
Corresponding address:
Jeremiah D. Dreisbach, MD, Desert Hematology Oncology Medical Group, Inc., 39800 Bob Hope Drive, Rancho Mirage, CA 92270, USA.
Email: dreisjd@hotmail.com
Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII inhibitor and lupus anticoagulant. Clinical findings included large hemorrhagic areas of the extremities, a prolonged activated partial thrombin time (aPTT) that did not correct with mixing studies and an elevated Bethesda assay. Treatment consisted of high-dose steroids with a tapering dosage. An acquired factor inhibitor should be considered in patients presenting with a prolonged aPTT that does not correct with mixing studies.
Keywords
Factor VIII inhibitor; lupus anticoagulant.
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