Diabetic ketoacidosis and prolonged
hyperchloraemic acidosis in a patient
treated with risperidone
Steven Fong, Alex Bazeos, Julia Thomas and Tahseen A. Chowdhury
Corresponding address:
Dr T.A. Chowdhury, Department of Diabetes and Metabolism,
7th Floor,
John Harrison House, The Royal London Hospital,
Whitechapel, London, E1 1BB, UK.
E-mail: tahseen.chowdhury@bartsandthelondon.nhs.uk
Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes. The development of
metabolic syndrome is widely recognised with the use of atypical antipsychotic agents, and not
infrequently DKA has been described with some of these drugs. We describe a complex patient
with HIV who presented with severe DKA and prolonged hyperchloraemic acidosis, which we
postulate was associated with risperidone therapy.
Keywords
Diabetic ketoacidosis; atypical anti-psychotics; hyperchloraemic acidosis; risperidone
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