Autoimmune neutropaenia complicating
Sjögren’s Syndrome: haematological and
clinical improvement with granulocyte
colony stimulating factor
M.D. Tarzi, S. Gupta, J Hanslip, H.J. Longhurst and A.S.M. Jawad
Corresponding address:
Dr A.S.M. Jawad,
Department of Rheumatology,
Barts and the London NHS
Trust,
Bancroft Road, London,
E1 4DG, UK.
E-mail: alismjawad1@hotmail.com
Connective tissue diseases are associated with granulocyte-specific autoantibodies and autoimmune
neutropaenia. Reduced levels of circulating neutrophils may predispose to recurrent
infections, particularly of the respiratory tract, although severe and opportunistic infections
have also been reported. There is only one previous description of the use of granulocyte colony
stimulating factor (GCSF) in Sjögren’s Syndrome complicated by autoimmune neutropaenia,
reporting poor response and tolerability. We present here the successful use of GCSF in a 42-yearold
woman with Sjögren’s Syndrome, autoimmune neutropaenia and chronic mastoiditis.
Keywords
Autoimmune neutropaenia; Sjögren’s Syndrome; granulocyte colony stimulating factor.
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