A case of chronic non-erosive sero-negative polyarthritis associated with pyoderma gangrenosum

We report a patient presenting with a seronegative polyarthritis who later developed pyoderma gangrenosum. The presumptive diagnosis was seronegative rheumatoid arthritis and associated pyoderma gangrenosum. However, the arthritis, although steroid responsive, did not respond to treatment with the usual DMARD therapies and appears to mirror the activity of the pyoderma gangrenosum. The normal X-rays, the negative rheumatoid factor and the normal colonoscopy are also consistent with a diagnosis of primary pyoderma gangrenosum with associated arthritis.