Metastatic prostate cancer presenting with hoarseness*
Irina Rybalova†, Claudia F. E. Kirsch‡, Jin K. Choe§ and Basil S. Kasimis¶
†Department of Medical Oncology and Hematology, Albert Einstein
College of Medicine, Montefiore Medical Center, 111 East 210th
Street, Bronx, New York 10467-2490, USA
‡Royal London Hospital and Bartholomew's Hospital, Flat 17 Eyre
Court, 3-21 Finchley Road, London, NW8 9TT, UK
§Department of Pathology, VA New Jersey Health Care Systems, 385
Tremont Avenue, East Orange, New Jersey 07018, USA
¶Department of Medical Oncology, VA New Jersey Health Care
Systems, 385 Tremont Avenue, East Orange, New Jersey 07018, USA
Department of Medical Oncology, Radiology and Pathology, VA New
Jersey Health Care Systems, East Orange, New Jersey, USA
Corresponding address: Dr Irina Rybalova, Attending Physician,
Department of Medical Oncology and Hematology, Albert Einstein
College of Medicine, Montefiore Medical Center, 111 East 210th
Street, Bronx, New York 10467-2490, USA.
E-mail: ir_doc@yahoo.com
Corresponding address: Basil S Kasimis, MD, Chief, Department of
Medical Oncology, VA New Jersey Health Care Systems, 385 Tremont
Avenue, East Orange, New Jersey 07018, USA
Metastatic involvement resulting in voice alteration may occur
from vocal cord infiltration or recurrent laryngeal nerve
involvement. We present a case of metastatic prostate
adenocarcinoma to the left infrahyoid neck compressing the
larynx resulting in hoarseness. A case report with one-year
follow-up is presented. The patient is a 65-year-old male with
hoarseness and a left infrahyoid prostate metastases measuring 8
by 10 cm, effacing the left pyrifom sinus and shifting the true
and false vocal cords to the right of midline, with cord
morphology and mobility maintained. Definitive radiation therapy
reduced the infrahyoid metastases with resolution of hoarseness.
Phonatory alteration from metastatic prostate carcinoma is rare.
We present a case of hoarseness resulting from displacement of
the larynx from infrahyoid metastases, which resolved after
reduction in size of the metastases with radiation therapy.
Key words
Prostate cancer; laryngeal compression; hoarseness.
* This case has been prepared for publication as a collaborative
work of the above physicians who were involved in the care of
this patient at the VA Hospital, East Orange, New Jersey.
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