A rare case of bone metastases from adenocarcinoma of the parotid gland
by J. Conibear, C. Jayadev, A. Sharma, P. Achan and S. Amen
A woman with known adenocarcinoma of the right parotid gland presented with bony metastasis in her left proximal femur. This was histologically confirmed and the patient underwent prophylactic intramedullary nail and hip screw fixation of her left proximal femur. This represents the first report of adenocarcinoma of parotid origin metastasising to a long bone in an adult. (Landmark Case Report: 22 July 2010) More...
Myasthenia gravis improvement in a patient receiving sunitinib for metastatic renal cell carcinoma
by Jean S.Z. Lee, Rateb Samman, Oliver C. Cockerell, Kate Fife and Tim Eisen
We present a case of a 59-year-old gentleman with myasthenia gravis and metastatic renal cell carcinoma that resolved on sunitinib. The clear temporal relationship between the patient receiving sunitinib for renal cell carcinoma and the resolution of his myasthenia gravis suggests that the improvement was due either to a paraneoplastic condition responding to treatment of the underlying malignancy or to a direct effect of sunitinib. (Neurology; Oncology; Urology: 22 July 2010) More...
Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
by Jeremiah D. Dreisbach, Luke P. Dreisbach, David E. Young and Philip B. Dreisbach
Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII inhibitor and lupus anticoagulant. Clinical findings included large hemorrhagic areas of the extremities, a prolonged activated partial thrombin time (aPTT) that did not correct with mixing studies and an elevated Bethesda assay. Treatment consisted of high-dose steroids with a tapering dosage. An acquired factor inhibitor should be considered in patients presenting with a prolonged aPTT that does not correct with mixing studies. (Specialties Haematology; Oncology: 6 Apr 2010) More...
Late recurrence of pelvic osteosarcoma: a case report and review of the literature
by B.G.I. Spiegelberg, K. Gokaraju, M.T. Parratt, A.M. Flanagan, S.R. Cannon and T.W.R. Briggs
A rare case of local recurrence of a high-grade osteosarcoma of the pelvis is described, 19 years after initial presentation, highlighting the need for continued long-term follow-up of patients with osteosarcoma. We review the literature concerning osteosarcoma of the pelvis, local recurrence and treatment with custom-made hemipelvic replacements. (Specialties Oncology; Orthopaedics: 16 Feb 2010) More...
Growing adrenal mass misdiagnosed as the cause of hirsutism in a patient with an ovarian Leydig cell tumor
by Maria H. P. Dietvorst, Suzanne Poots and Peter van Wijngaarden
A case is described involving a 71-year-old hirsute woman with a growing adrenal tumor and a high serum testosterone level, which did not normalize after adrenalectomy. Following this she was found to have a testosterone-producing ovarian Leydig cell tumor. This case provides key features that can help distinguish adrenal and ovarian causes of hirsutism. (Specialties Oncology: 17 Nov 2009) More...
Late metastases to the pancreas from resected renal cell carcinoma masquerading as multiple endocrine neoplasia
by Danijela Tatovic, David Farrugia, Frank Jewell and Thomas Ulahannan
We report the case of 58-year-old gentleman with pancreatic masses, possibly of neuroendocrine origin, with the history of renal carcinoma, primary hyperparathyroidism and pituitary cyst. Histological analysis after pancreatectomy revealed metastases from renal cancer. This unusual case illustrates the challenging differential diagnosis between multiple endocrine neoplasia (MEN) syndrome and metastatic renal cell cancer. (Specialties Endocrinology, Oncology: 28 May 2009) More...
Metastatic prostate cancer presenting with hoarseness
by Irina Rybalova, Claudia F. E. Kirsch, Jin K. Choe and Basil S. Kasimis
Metastatic involvement resulting in voice alteration may occur from vocal cord infiltration or recurrent laryngeal nerve involvement. We present a case of metastatic prostate adenocarcinoma to the left infrahyoid neck compressing the larynx resulting in hoarseness. A case report with one-year follow-up is presented. The patient is a 65-year-old male with hoarseness and a left infrahyoid prostate metastases measuring 8 by 10 cm, effacing the left pyrifom sinus and shifting the true and false vocal cords to the right of midline, with cord morphology and mobility maintained. Definitive radiation therapy reduced the infrahyoid metastases with resolution of hoarseness. Phonatory alteration from metastatic prostate carcinoma is rare. We present a case of hoarseness resulting from displacement of the larynx from infrahyoid metastases, which resolved after reduction in size of the metastases with radiation therapy.
(Oncology, Ear, nose and throat; May 2005) More...
Hypothyroidism presenting as recurrence of previously surgically decompressed carpal tunnel syndrome
by V. Reid, A. S. M. Jawad and J. D. Perry
We report the case history of a 45-year-old woman who presented with symptoms of bilateral carpal tunnel syndrome 8 years after a successful surgical decompression of both tunnels. (Endocrinology, General surgery; April 2005) More...
Renal colic: an unusual presentation of non-Hodgkin's lymphoma of the urinary bladder
Secondary involvement of the urinary bladder in non-Hodgkin's lymphoma is relatively common, but primary malignant lymphomas of this organ remain exceedingly rare. We report a case presenting atypically with renal colic and briefly review the relevant literature(May 2004)More...
Squamous cell carcinoma complicating chronic osteomyelitis
The internal fixation of fractures is associated with a risk of infection. Open fractures in particular are susceptible to such infection. Treatment is difficult and patients can develop a chronic osteomyelitis. We present the case of a patient who developed chronic osteomyelitis with a persistent discharging sinus following internal fixation of an open fracture of tibia. (March 2004) More...
Foster Kennedy syndrome secondary to oligodendroglioma
Foster Kennedy syndrome (FKS) is rare.It is characterised by the presence of ipsilateral optic atrophy,contralateral papilloedema and ipsilateral anosmia.Since its first description in 1911, it has never been reported in oligodendroglioma. (January 2004) More...
Giant hemangioma or metastatic disease of malignant gastrointestinal tumor? Diagnoses through ‘new-line’ therapy
In a case of a malignant gastrointestinal stromal tumor (GIST) with a huge hepatic metastatic lesion of undetermined origin, the lesion shrank markedly during therapy with a highly selective tyrosine kinase inhibitor. (June 2003) More...
Paraneoplastic Syndrome Presenting as Progressive Cognitive Decline
A number of paraneoplastic neurological syndromes have been described in association with small cell lung carcinoma and, less commonly, with other malignancies. We describe here the case of a 58-year-old woman with paraneoplastic limbic encephalitis (PLE) complicating squamous cell carcinoma of the lung. (August 2002) More...
Atypical Metastases From Squamous Cell Cancers
Relapse of squamous cell carcinomas usually occurs in a predictable pattern. We present two patients with rare metastases. The first developed peritoneal disease without evidence of intra-thoracic spread due to a laryngeal cancer. The second, a patient with a vulval squamous tumour, was presented with distant disease following foot pain. (July 2002) More...
An Unusual Primary Pulmonary Carcinoma
ACC is an unusual pulmonary neoplasm, accounting for 0.09%-0.2% of all lung cancers. It is a low-grade tumour with unusual histological features and rarely metastasises outside the lungs. We describe a case with bilateral renal metastases. (July 2002) More...
