Myasthenia gravis improvement in a patient receiving sunitinib for metastatic renal cell carcinoma
by Jean S.Z. Lee, Rateb Samman, Oliver C. Cockerell, Kate Fife and Tim Eisen
We present a case of a 59-year-old gentleman with myasthenia gravis and metastatic renal cell carcinoma that resolved on sunitinib. The clear temporal relationship between the patient receiving sunitinib for renal cell carcinoma and the resolution of his myasthenia gravis suggests that the improvement was due either to a paraneoplastic condition responding to treatment of the underlying malignancy or to a direct effect of sunitinib. (Neurology; Oncology; Urology: 22 July 2010) More...
A case of Epstein–Barr virus (EBV) meningoencephalitis in a patient with rheumatoid arthritis
by Dennis Nyuk Fung Lim
A case of Epstein–Barr virus (EBV) meningoencephalitis in a 74-year-old white man with rheumatoid arthritis is reported. The potential predisposing factors for EBV meningoencephalitis, the diagnostic approach and the management highlighted by this case are discussed. (Specialties Infection and immunity; Neurology; Rheumatology: 31 Dec 2009) More...
An unusual case of 'collapse query cause'
by A Barclay and C Weaver
A 60-year-old woman attended A&E following an unwitnessed 'collapse query cause'. Over 4 months she recalled involuntary movement of her eyes and head to the left and, on one occasion, complete rotation of her body. She had subtle neurological signs. Imaging identified the cause of these adversive seizures. (Accident and Emergency Medicine and Surgery (including Trauma); Neurology; 13th June 2007) More...
An acute on chronic presentation of Vogt-Koyanagi-Harada (VKH) disease
by Aryan Lawe, Gareth Lewis and Mark Westcott
VKH disease is an idiopathic chronic granulomatous inflammatory disorder. It has ophthalmic, neurological and cutaneous manifestations. The clinical picture is variable and dependent on the stage of presentation. We report on a patient who presented with a mixed picture of early and late onset symptoms with clinical findings of acute on chronic inflammation. (Ophthalmology, Neurology; May 1st 2006) More...
Semantic processing in a coma patient
by Boris Kotchoubey, Jerome Daltrozzo, Norma Wioland, Veronique Mutschler, Philippe Lutun, Niels Birbaumer and Albert Jaeger
Electrical brain responses to words semantically related versus unrelated to their context were recorded in a coma patient on days 6 (Glasgow Coma Scale, GCS = 6) and 22 (GCS = 9). Significant differences between related and unrelated words (which were completely matched in their physical features) were consistently observed in both examinations. This is the first evidence for semantic stimulus processing in coma. (Neurology, Medical psychology, Critical care; September 2005) More...
Paraneoplastic Syndrome Presenting as Progressive Cognitive Decline
A number of paraneoplastic neurological syndromes have been described in association with small cell lung carcinoma and, less commonly, with other malignancies. We describe here the case of a 58-year-old woman with paraneoplastic limbic encephalitis (PLE) complicating squamous cell carcinoma of the lung. (August 2002) More...
‘Expressed’ Dysphasia
An ironic poem written at the time of a transient ischaemic attack is illustrated which demonstrates the expressive nature of dysphasic dysgraphia at the moment of the attack. (July 2002) More...
