Spontaneous liver haematoma as a result of thrombolytic therapy
by Jeremy Lynch and Simon Etkind
Spontaneous liver haemorrhage due to thrombolysis is an extremely rare and life-threatening condition. This is the only report of spontaneous liver haemorrhage following thrombolysis in the literature that has been managed non-operatively, and proves such an approach is possible. The clinical findings and management of this case are discussed in relation to the relevant literature. (Cardiology; General surgery; Hepatology: 22 July 2010) More...

Thrombotic thrombocytopenic purpura (TTP) associated with interferon therapy of hepatitis C
by Iryna S. Hepburn and Robert Schade
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is a rare but known complication of chronic viral hepatitis C (HCV). Even less frequently treatment of HCV with interferon-alpha (INFα) may become complicated with TTP/HUS, although only a few such reports have been published. We report a 43-year-old woman who developed TTP on two separate occasions soon after beginning treatment with IFN-alpha and ribavarin for HCV. (Specialties Gastroenterology; Hepatology: 16 Feb 2010) More...

Spontaneous biliary peritonitis: two unusual cases
Two patients with biliary peritonitis without demonstrable perforation are described. Despite
biliary peritonitis almost invariably following biliary tract perforation, none could be identified
with contemporary imaging. This condition is extremely rare, difficult to diagnose pre-operatively and has high mortality. ( August 2004) More...